Project Description
PhD Subject: Biotechnology
Within the framework of a new long-term project aimed at better understanding the underlying cause and developing medical treatment strategies for Welanders Distal Myopathy, a doctoral position is announced in biological pharmaceuticals and stress granules.
The project will aim to develop model systems that mimic muscle cells in the disease where a disease-related gene is mutated, as well as treatment strategies with biological pharmaceuticals. Both the development of binding molecules and gene therapy vectors will be part of the project. In our research group, we work together - laboratory technicians, doctoral students, postdoctoral researchers, and scientists - with engineering and production of biological molecules such as antibodies, Affibody molecules, and adeno-associated viruses for therapeutic applications and to better understand diseases. We also work with mammalian cell line development where systems biology, OMICS methods, and CRISPR/Cas9 are important tools.
Supervision: Johan Rockberg is proposed to supervise the doctoral student. Final decision will be made upon admission.
We Offer
- The opportunity to pursue a PhD at KTH.
- A workplace with many benefits and monthly salary according to the doctoral salary scale.
Eligibility for Admission
To be admitted to doctoral studies, the following basic qualifications are required:
- Completed advanced level degree, or
- Completed course requirements of at least 240 higher education credits, of which at least 60 credits at advanced level, or
- Acquired equivalent knowledge through other means within or outside the country.
Special eligibility requirements:
- Documented experience handling patient materials (blood and/or tissue)
- Experience in biological pharmaceutical production in CHO cells, including antibody production and purification
- Experience in viral vector production for gene therapy applications
- Experience in quality control of viral vectors using methods such as qPCR
- Experience in cloning, protein expression in E. coli, and purification
- Experience with analytical methods such as SDS-page, Western blot, ELISA
Additional admission requirements are available on the KTH website.
Selection
To succeed in your doctoral studies at KTH, you need to be goal-oriented and persistent in your work. Candidates will be assessed on their ability to:
- Work independently
- Collaborate with others
- Maintain a professional approach
- Analyze and work with complex issues
Personal qualities will be given significant weight after meeting the eligibility requirements.
Target Degree: Doctoral Degree
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